The flexiWAVE has been thought and engineered as a ‘microwave platform’, where all types of commonly used glassware could be used.
This clearly results in a very flexible system, with a wide range of applications capabilities. The Classic Glassware setup, for instance, provides the suitable apparatus for a full reaction optimization, for research or teaching pourposes.
It allows the chemists to perform synthetic reactions under reflux and, in this manner, any chemical reaction currently carried out with hot plates, heating mantles or oil baths, could be rapidly improved by adopting microwave technology.
Stubborn reactions are typically carried out in refluxing conditions, using high boiling solvents such as xylenes, 1,2-
dichlorobenzene and N-methyl pyrrolidone.
High boiling solvents are then difficult to remove upon workup, especially as reaction scale increases.
The High-Pressure setup is capable of replacing reflux devices, moving from high boiling solvents to low boiling solvents. Moreover, high temperature reactions (up to 300 C) are allowed.
The benefits are well known and documented in terms of easier work-up and products purity. Up to 15 high-pressure vessels may be used simultaneously for parallel synthesis.
Heating heterogeneous reaction mixtures, thick media or solid phase systems suffers of inhomogeneous temperature
distribution and stirring difficulties using conventional microwave instruments.
The innovative Solid-Phase setup offers the unique capability of physically rotate the reaction vessel, to achieve very homogenous bulk heating of slurries, viscous and solid reaction mixtures media.
The reaction temperature is controlled by a contact-less infrared sensor.
Furthermore, the Solid-Phase setup allows operations under normal atmosphere, inert gas, and vacuum.
Functionalization and modifications of materials, polycondensation, coating, dehydration of natural oils are some of the most common area of application.
The new Milestone synthWAVE is designed for safe, reliable and reproducible scale-up of microwave enhanced chemical reactions. It handles single or multiple reactions at temperatures up to 300 °C and pressures to 199
bar. Small-scale synthesis methods are easily transferred to the synthWAVE. Incredibly easy to use, the synthWAVE allows the chemist to run large-scale batch and parallel reactions like never before.
The combination of high microwave power density of 1.5kW/L and powerful stirring allows the same conditions developed for smallscale reactions to be replicated. Multiple reactions are carried out simultaneously under exactly the same temperature and pressure conditions – even using different solvents. Quickly and easily evaluation of different catalysts, solvents and reaction conditions.
The synthWAVE allows for the use of a wider range of low-boiling reagents, reactants and solvents. Perform aqueous reactions and extractions below boiling point. Extremely efficient cooling of the reaction vessel avoids or minimizes degradation and side reactions. Simply add an inert gas to achieve an inert environment. Add hydrogen or oxygen to produce a reducing or oxidizing atmosphere respectively. Speed up reactions with gas molecule insertion using gases such as CO or CO2. Example: the preparation of isocyanates derivatives by the Staudinger-Aza-Wittig reaction.