SRC Technology
The ultraWAVE is based on the SRC (Single Reaction Chamber technology), invented by Milestone several years ago (Patents pending). SRC technology achieves extraordinary performance capabilities combining microwave heating with a high-pressure reactor which acts simultaneously as microwave cavity and vessel. The ultraWAVE chamber is sealed, pressurized, heated, cooled, vented, and opened via a dedicated touch-screen control terminal. Loading a rack of samples into the chamber is the only manual operation in an otherwise fully automated process of microwave-assisted sample preparation. The outer surfaces of the vessel remain at room temperature throughout the entire microwave heating cycle. As a result, the ultraWAVE is dramatically less labor intensive and easier to use compared to conventional microwave digestion systems.
Books
Milestone Books
Readable texts for practical analysts and for everyone interested in the evolution of sample preparation strategies.
Getting ready for USP 232 and 233
Microwave-Assisted Sample Preparation and Determination of Elemental Impurities in Pharmaceutical Products
Easy-to-use technology
for optimized workflow
Operating Sequence
1. Loading
At the core of the ultraWAVE is a TFM-lined reaction vessel. Samples are weighed into vials, and suitable reagents are added. Rack with vials is automatically lowered into the reaction chamber.
2. Closing and pressurizing
The chamber is sealed and pressurized with inert gas, which physically acts as a cap for the vials, avoiding boiling of the solutions and preventing cross contamination.
3. Heating and cooling
Microwave energy is applied, with all samples at the same temperature and pressure conditions. At the end of the
microwave run, a cooling device rapidly lowers the temperature of the solutions.
4. Pressure release and opening
The entire rack is automatically lifted up to facilitate the
removal of the solution vials. As a visual aid for the user, the color of the backlit logo indicates the process status.
Safety
Like all Milestone products, the ultraWAVE has been designed with operator safety of paramount importance: it has been developed for being used with any acid or combination thereof, and every single reactor is tested at a pressure up to 330 bar.
A thick acrylic shield surrounds the working area, and runs cannot be started unless the chamber clamps are in correct position. Temperature and pressure are monitored 20 times/sec, automatically adjusting microwave power to control even highly exothermic reactions.
Any sample, any time
The benefits of SRC Technology
Efficient and Cost-Effective
High Productivity
Compared to any other conventional microwave digestion systems, the ultraWAVE is significantly easier to use, thus dramatically improving the laboratory work flow. Up to 26 samples are processed in 45 minutes start to finish. Ease to say that the ultraWAVE sample
throughput is far better than any other microwave systems.
All samples are processed in a single run at the same temperature and pressure, eliminating the need to run multiple digestion cycles for different samples or matrices. The use of disposable glass vials eliminates the cleaning step, further enhancing the ultraWAVE productivity.
All samples are processed in a single run at the same temperature and pressure, eliminating the need to run multiple digestion cycles for different samples or matrices. The use of disposable glass vials eliminates the cleaning step, further enhancing the ultraWAVE productivity.
Smart software
designed around you
The ultraWAVE is controlled via a compact external terminal with an easy-to-read, bright, full-color, touchscreen display. Multiple USB and Ethernet ports are provided, for interfacing the instrument to external devices and to the local laboratory network. The terminal runs the Milestone easyWAVE, a completely new user-friendly, icon-driven, and multi-language software. Just recall a previously stored method or create a new one; press the Start icon and the system will automatically follow the user defined temperature profile using a sophisticated PID algorithm.
Hundreds of applications, including all US EPA methods, are preloaded, eliminating any need for method development.
Hundreds of applications, including all US EPA methods, are preloaded, eliminating any need for method development.
Milestone
Validation Package
The Milestone ultraWAVE allows for the complete digestion and the complete recovery of all elements of any pharmaceutical sample, as specified by USP 232/233, ICHQ3D and EP 5.20 methods. Different sample matrices (powders, tablets, liquids, etc.) are digested with a single microwave program. The instrument operating software is compliant with the requirements of 21 CFR Part 11. A comprehensive Milestone
Validation Package is available, to assure the complete qualification of the instrumentation.
Need to fulfill regulatory requirements?
The Milestone Validation Packages include several
protocols in order to fulfill regulatory requirements, such
as the Good Manufacturing Practice (GMP) guidelines
that, along with our superior support and expertise, will
be by your side throughout the whole process. Our
experts will support you with the right confi guration,
with a dedicated procedure for your samples, with a
demonstration of the system’s capabilities and with
a complete validation package that includes: DQ
(Design Qualification), IQ (Installation Qualification),
OQ (Operational Qualification), PQ (Performance Qualification) and the requalification. All the tests
carried out by our service engineers are guaranteed by
certified test equipment, providing high accuracy and
meeting all the regulatory requirements. Our software is fully compliant with the FDA regulation
21 CFR part 11, with an exhaustive audit trail for
complete traceability. The MVP is one of the multiple
services offered by Milestone to ensure the highest
industry standards in customer support.
Connect with us
Contact us directly by phoning at +39 035.573857
or discover your National Representative to get local support.
or discover your National Representative to get local support.
Milestone Srl
Via Fatebenefratelli 1/5 - 24010 Sorisole (BG) - Italy
Phone: +39 035.573857 | Fax: +39 035.575498
Via Fatebenefratelli 1/5 - 24010 Sorisole (BG) - Italy
Phone: +39 035.573857 | Fax: +39 035.575498
Milestone Srl
Via Fatebenefratelli 1/5 - 24010 Sorisole (BG) - Italy
Phone: +39 035.573857 | Fax: +39 035.575498
Via Fatebenefratelli 1/5 - 24010 Sorisole (BG) - Italy
Phone: +39 035.573857 | Fax: +39 035.575498