The Milestone synthWAVE is designed for safe, reliable and reproducible scale-up of microwave enhanced chemical reactions. The synthWAVE is capable of higher temperature and pressure than any other microwave reactors.
Milestone synthWAVE features the unmatched Single
Reaction Chamber (SRC) patented technology that ensures
scale, reaction screening, highest temperature and pressure. It is able to handle single or multiple reactions at temperatures up to 300 °C and pressures up to 199 bar.
Incredibly easy to use, the synthWAVE with SRC technology allows the
chemist to run large-scale batch and parallel reactions
like never before. Small-scale synthesis methods are easily transferred to the SynthWAVE.
Milestone’s unique Single Reaction Chamber (SRC) technology overcomes the limitations of current microwave synthesis
instrumentation. A PTFE lined, 1 L stainless steel reaction chamber serves also as microwave cavity. The design of the microwave source perfectly match the cavity shape for optimum
microwave distribution and fast, even heating.
The chamber is prepressurized with gas to prevent boiling of the solution, and is equipped with mechanical and magnetic
The microwave cavity is water cooled, which greatly reduces reaction cooling time and increases productivity.
Like all Milestone products, the synthWAVE has been designed with operator safety of paramount importance.
A thick acrylic shield surrounds the work area, and it lowers into position automatically as the chamber is closed.
A microwave run cannot be started unless the chamber clamp is in position, and the clamp cannot be released until the chamber is cool, and pressure has been released.
The PID controller continuously monitors temperature and pressure, instantaneously adjusting microwave power to control even highly exothermic reactions.
The synthWAVE features a powerful stirrer, which ensures
vigorous stirring in the 1L PTFE vessel, or in all vials whenever a rack is used, thus assuring reliable and consistent results.
How the synthWAVE works
Acrylic safety shield
In-situ sampling Easily and conveniently sample reaction
products at any time during the experiment.
Analog pressure gauge
PTFE 1 L vessel
RACK AND VIALS
Reactions can be carried out directly in the 1L
PTFE vessel, or in multiple vials.
Vials are available in glass (disposable), quartz
or PTFE, fitted with loose PTFE caps to ensure
Available rack configurations include 4, 5, 15
and 22 positions.
The synthWAVE sample racks fit easily on a
balance, so reagents can be weighed directly
into vials already loaded into a rack.
No vessel assembly or disassembly is
required, and with the disposable glass vials,
no cleaning step is needed, greatly increasing
Multiple reactions are carried out
simultaneously under exactly the same
temperature and pressure conditions - even
using different solvents.
Quickly and easily evaluation of different
catalysts, solvents and reaction conditions.
OPERATE IN MODIFIED CONDITIONS
Simply add an inert gas to achieve an inert
Add hydrogen or oxygen to produce a reducing
or oxidizing atmosphere respectively.
Speed up reactions with gas molecule insertion
using gases such as CO or CO2.
synthWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network.
The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation.
easyCONTROL Operating Software
synthWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation.
Oxidations and Reductions
Esterification & Ammidation
Modification of carbon nanotubes
Reactions with sensitive reagents and materials
Reagents and Materials
Subcritical fluids extracion
C-C, C-X Couplings
One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza- Wittig reaction.
D. Carnaroglio et al., Beilstein J. Org. Chem., 2013, 9, 2378-2386
Pd/C-catalyzed aerobic oxidative esterification of alcohols and aldehydes: a highly efficient microwave-assisted green protocol.
M. Caporaso et al., Beilstein J. Org. Chem. 2014, 10, 1454–1461
Highly Efficient Microwave-Assisted CO Aminocarbonylation with a Recyclable Pd(II)/TPP-ß-Cyclodextrin Cross-Linked Catalyst.
E. Calcio Gaudino et al., Org. Process Res. Dev. 2015, DOI: 10.1021/op5003374
A novel SWCNT platform bearing DOTA and β-cyclodextrin units. “One shot” multidecoration under microwave irradiation.
E. Calcio Gaudino et al., Org. Biomol. Chem. 2014, 12, 4708- 4715