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Unique technology
for high pressure capabilities

The Milestone synthWAVE features the unique Single Reaction Chamber (SRC) patented technology that ensures scale, reaction screening, highest temperature and pressure. It is able to handle single or multiple reactions at temperatures up to 300 °C and pressures to 199 bar.
Incredibly easy to use, the synthWAVE allows the chemist to run large-scale batch and parallel reactions like never before. Small-scale synthesis methods are easily transferred to the SynthWAVE.
  • Minutes, not hours
  • Improved yelds
  • Enhanced selectivity
  • Low energy consumption
  • Sustainable approach

Book

Book

Microwave Chemistry

Microwave Chemistry describes the state-of-the-art of microwave (MW) technology and its applications in chemistry.
synthWAVE Schematics
Magnetron
Waveguide
Reaction chamber
Stirrer
  • Magnetron
  • Waveguide
  • Reaction chamber
  • Stirrer

New horizons in microwave chemical synthesis

SRC Technology

Milestone’s unique Single Reaction Chamber (SRC) technology overcomes the limitations of current microwave synthesis instrumentation. A PTFE lined, 1 L stainless steel reaction chamber serves also as microwave cavity. The design of the microwave source perfectly match the cavity shape for optimum microwave distribution and fast, even heating. The chamber is prepressurized with gas to prevent boiling of the solution, and is equipped with mechanical and magnetic stirrers. The microwave cavity is water cooled, which greatly reduces reaction cooling time and increases productivity.

Safety

Like all Milestone products, the synthWAVE has been designed with operator safety of paramount importance. A thick acrylic shield surrounds the work area, and it lowers into position automatically as the chamber is closed. A microwave run cannot be started unless the chamber clamp is in position, and the clamp cannot be released until the chamber is cool, and pressure has been released. The PID controller continuously monitors temperature and pressure, instantaneously adjusting microwave power to control even highly exothermic reactions.

Software-controlled stirrer

The synthWAVE features a powerful stirrer, which ensures vigorous stirring in the 1L PTFE vessel, or in all vials whenever a rack is used, thus assuring reliable and consistent results.

How the synthWAVE works

How the synthWAVE works
Acrylic safety shield
Overhead stirrer
In-situ sampling
Easily and conveniently sample reaction products at any time during the experiment.
Gas outlet
Gas inlet
Analog pressure gauge
15-place rack
Exhaust system
Temperature sensor
Clamps
PTFE 1 L vessel
Dewar flask
Control terminal
  • Acrylic safety shield
  • Overhead stirrer
  • In-situ sampling
    Easily and conveniently sample reaction products at any time during the experiment.
  • Gas outlet
  • Gas inlet
  • Analog pressure gauge
  • 15-place rack
  • Exhaust system
  • Temperature sensor
  • Clamps
  • PTFE 1 L vessel
  • Dewar flask
  • Control terminal
RACK AND VIALS
Reactions can be carried out directly in the 1L PTFE vessel, or in multiple vials. Vials are available in glass (disposable), quartz or PTFE, fitted with loose PTFE caps to ensure pressure equalization. Available rack configurations include 4, 5, 15 and 22 positions. The synthWAVE sample racks fit easily on a balance, so reagents can be weighed directly into vials already loaded into a rack. No vessel assembly or disassembly is required, and with the disposable glass vials, no cleaning step is needed, greatly increasing work efficiency.
FASTER SCREENING
Multiple reactions are carried out simultaneously under exactly the same temperature and pressure conditions - even using different solvents. Quickly and easily evaluation of different catalysts, solvents and reaction conditions.
OPERATE IN MODIFIED CONDITIONS
Simply add an inert gas to achieve an inert environment. Add hydrogen or oxygen to produce a reducing or oxidizing atmosphere respectively. Speed up reactions with gas molecule insertion using gases such as CO or CO2.

easyCONTROL
Operating Software

synthWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network.
The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation.

easyCONTROL
Operating Software

synthWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation.
synthWAVE Control Terminal

Applications

  • Oxidations and Reductions
  • Esterification & Ammidation
  • Coating
  • Polymerization
  • Nanoparticles preparation
  • Modification of carbon nanotubes
  • Reactions with sensitive reagents and materials
  • Desulphurization
  • Cycloadditions
  • Reagents and Materials
  • Click chemistry
  • Gas insertion
  • Multicomponent reactions
  • Dechlorination
  • Subcritical fluids extracion
  • Stereoselective transformations
  • C-C, C-X Couplings
synthWAVE applications
One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza- Wittig reaction.
D. Carnaroglio et al., Beilstein J. Org. Chem., 2013, 9, 2378-2386
synthWAVE applications
Pd/C-catalyzed aerobic oxidative esterification of alcohols and aldehydes: a highly efficient microwave-assisted green protocol.
M. Caporaso et al., Beilstein J. Org. Chem. 2014, 10, 1454–1461
synthWAVE applications
Highly Efficient Microwave-Assisted CO Aminocarbonylation with a Recyclable Pd(II)/TPP-ß-Cyclodextrin Cross-Linked Catalyst.
E. Calcio Gaudino et al., Org. Process Res. Dev. 2015, DOI: 10.1021/op5003374
synthWAVE applications
A novel SWCNT platform bearing DOTA and β-cyclodextrin units. “One shot” multidecoration under microwave irradiation.
E. Calcio Gaudino et al., Org. Biomol. Chem. 2014, 12, 4708- 4715

What our Clients say

  • Efficient, sustainable and scalable synthetic protocols require the Milestone synthWAVE as irreplaceable tools in modern chemistry for its unique versatility.

    Prof. G. Cravotto, University of Turin

    Read more

  • The synthWAVE has greatly increased the effi ciency and productivity of hydrothermal protocols and has expanded the experimental capabilities for the whole group.

    Prof Ajayan Vinu, Future Industries Institute, University of South Australia

    Read more

What our Clients say

  • Efficient, sustainable and scalable synthetic protocols require the Milestone synthWAVE as irreplaceable tools in modern chemistry for its unique versatility.

    Prof. G. Cravotto, University of Turin

    Read more

  • The synthWAVE has greatly increased the effi ciency and productivity of hydrothermal protocols and has expanded the experimental capabilities for the whole group.

    Prof Ajayan Vinu, Future Industries Institute, University of South Australia

    Read more

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