MULTISYNTH: Breakthrough Thinking

Microwave Organic Synthesis System

The new Milestone MULTISYNTH is an innovative, compact, and versatile system for enhanced microwave organic synthesis. It features single-mode and multi-mode microwave technologies in a single unit, thus allowing for batch and parallel reactions with user selection of continuous or pulsed microwave emission. It performs reflux and pressurized reactions with easy scale-up from 0,25 to 35 ml. Accurate and precise reaction temperature control is provided by unique state-of-the-art sensors in single or multiple vessels, for safe and reproducible working conditions. The MULTISYNTH offers magnetic stirring capabilities and an exclusive vessel ‘vibration’ system, to ensure homogeneous temperature distribution throughout the solutions in single or multiple vessels. High-efficiency cooling capabilities contribute to enhanced reaction yield during the microwave run, and to reaction quenching at the end of the run.

The benefits of Microwave-Enhanced synthesis

Microwave-enhanced chemistry represents a major step forward in the capabilities of synthetic chemists. Since its introduction, it has allowed organic chemists to run reactions faster than ever before, with higher yields, and to scale up experiments reliably from milligrams to much larger quantities without the need to alter reaction parameters.
Microwave-enhanced synthesis offers much more precise control over conditions of temperature and pressure than any alternative technologies, and unsurpassed ease of use. Today, microwave-enhanced chemistry has become a cutting-edge technology across the pharmaceutical, bio-tech, polymers and plastics, and fine- and agrochemical industries, with thousands of systems installated worldwide.

Single-Mode and Multi-Mode

The Milestone MultiSYNTH combines all the inherent advantages of the single-mode microwave technology, such as fast heating, full control of single reactors, and fast cooling, with all the benefits of multi-mode cavities, such as the ability to run multiple reactions in parallel with complete reproducibility.

Single-mode setup features
In the single-mode setup a single vessel direclty located in the dedicated single-mode position, in correspondence with the highest energy intensity of the microwave irradiation.

Multi-mode setup
In the multi-mode setup a carousel rotates in the microwave cavity, ensuring fast and homogeneous heating of all reaction vessels.

Milestone MultiSYNTH Features

FEATURES	SINGLE-MODE SETUP	MULTI-MODE SETUP
Volume working range	1 vial with 0,25 to 35 ml	up to 12 vials with 0,25 to 5 ml
		up to 6 vials with 10-35 ml
		1 batch reactor at atmospheric pressure up to 500 ml
Contact-less temperature control	Yes, by infrared	Yes, sequentially by infrared in each vial
Direct temperature control	Yes, by fiber optic	Yes, by fiber optic in a reference vial
Pressure control	Yes, built-in to reaction vials safety valve	PFA
Magnetic stirring	Yes	Yes, in batch reactor
Shaking	Yes	Yes, in all vials
Cooling	Yes, by compressed air	Yes, sequentially by compress air