Why MicroSYNTH ?
The Benefits
of Microwave
Enhanced
Organic
Synthesis
Microwave enhanced chemistry represents a fundamental
step forward in the capabilities of synthetic chemists. Since its
introduction, it has allowed organic chemists to run reactions
faster than ever before and with higher yields, and to scaleup
experiments reliably from milligrams to much larger
quantities without the need to alter reaction parameters.
Microwave enhanced chemistry offers much more precise
control over temperature and pressure conditions than any
alternative technology, and unsurpassed ease of use. The
total number of papers on microwave synthesis has grown
quickly in recent years, from about 300 in 1995 to over 3000
in 2006! Today, microwave enhanced organic synthesis has
become a cutting-edge technology across the
pharmaceutical, biotech, polymers, fine- and agro-chemical
industries, with thousands of installations worldwide.
Reaction homogeneity
In standard mono-mode microwave systems, the
wavelength of the microwaves corresponds to the size
of the oven chamber, and standing wave patters are
allowed to form. Microwaves must be focused through
a wave guide on the reaction vial, meaning that only
one vessel can be used. Fu rthermore, there are
restrictions on the vessel volumes.
Conventional Microwave
(EtOH, 80°C) (EtOH, 120°C) |
Microwave
(EtOH, 80°C) (EtOH, 120°C) |
Time (min.) |
Yield (%) |
Time (min.) |
Yield (%) |
360 |
70 |
10 |
75 |
 The MicroSYNTH offers such excellent scalability
because of its multi-mode design. The microwave field
is diffused homogeneously throughout the entire
chamber by means of a mode stirrer. As a result,
chemists can achieve uniform results in a wide range of
vials or well plates, and can process multiple reactions
simultaneously or explore larger reaction volumes.
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