MICROWAVE SCIENCE FOR BETTER CHEMISTRY
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Why MicroSYNTH ?

The Benefits of Microwave Enhanced Organic Synthesis

Microwave enhanced chemistry represents a fundamental step forward in the capabilities of synthetic chemists. Since its introduction, it has allowed organic chemists to run reactions faster than ever before and with higher yields, and to scaleup experiments reliably from milligrams to much larger quantities without the need to alter reaction parameters. Microwave enhanced chemistry offers much more precise control over temperature and pressure conditions than any alternative technology, and unsurpassed ease of use. The total number of papers on microwave synthesis has grown quickly in recent years, from about 300 in 1995 to over 3000 in 2006! Today, microwave enhanced organic synthesis has become a cutting-edge technology across the pharmaceutical, biotech, polymers, fine- and agro-chemical industries, with thousands of installations worldwide.

Reaction homogeneity

In standard mono-mode microwave systems, the wavelength of the microwaves corresponds to the size of the oven chamber, and standing wave patters are allowed to form. Microwaves must be focused through a wave guide on the reaction vial, meaning that only one vessel can be used. Fu rthermore, there are restrictions on the vessel volumes.

Conventional Microwave
(EtOH, 80°C) (EtOH, 120°C)

Microwave
(EtOH, 80°C) (EtOH, 120°C)

Time (min.)

Yield (%)

Time (min.)

Yield (%)

360

70

10

75

 

The MicroSYNTH offers such excellent scalability because of its multi-mode design. The microwave field is diffused homogeneously throughout the entire chamber by means of a mode stirrer. As a result, chemists can achieve uniform results in a wide range of vials or well plates, and can process multiple reactions simultaneously or explore larger reaction volumes.