Medicinal Chemistry and Reaction Optimization

MonoPREP Module

The MonoPREP module is designed for rapid and reproducible reaction optimization at elevated temperatures and pressures, using a single 12 ml or 50 ml reactor vessel. With its very fast cooling (close to 30ºC/min.), support for small volumes (as low as 2 ml), and choice of glass or quartz reactors, the MonoPREP is one of the most popular accessories in Milestone’s wide range of tools.

• Fast heating. Reactions can be set to reach their target temperatures in a minimum of time.
• Stirring of solutions. The labstation’s built-in magnetic stirring works well with the MonoPREP.
• Temperature control. In-vessel temperature monitoring is performed by an in-vessel fiber-optic probe, for intimate contact with the reaction mixture to ensure extreme precision. An infrared sensor monitors the surface temperature of the vessel for added safety.
• Fast and effective cooling. A unique air flow pattern (shown below) cools the reactor at close to 30ºC/minute.
• Fast and effective cooling.A unique air flow pattern (shown below) cools the reactor at close to 30ºC/minute.
• Flexibility. The MonoPREP supports 12 ml or 50 ml reactor vessels, in glass or quartz.

MedCHEM Kit

The highly flexible MedCHEM Kit, for use with Milestone’s MicroSYNTH labstation, offers reaction vessels and sample processing tools for drug discovery work, ranging from 2 ml to 160 ml. Each chemist can have his own kit of reactors, providing total control and limiting the risk of contamination. A researcher can walk up to the MicroSYNTH microwave, process his samples in his own reactors, and take the samples back to his own workbench to finish them for analysis.

• Flexibility. With Milestone’s specialized MedCHEM accessories, the medicinal chemist can process single reaction volumes from 2 ml up to 160 ml.
• Based on your experience. Input from hundreds of pharmaceutical users helped us to develop the right tools for drug discovery and scale-up.
• User friendly. Milestone’s software and accessories are often praised by pharmaceutical users for ease of use. Our technology does its work unobtrusively, and that transparent ease of use leaves chemists free to focus on chemistry rather than microwave technology.
• Smooth implementation. Move from conventional heating to the MicroSYNTH platform without altering chemistry or solvents, with our unique multi-mode cavity and proprietary Weflon heating elements.