StartSYNTH Flexibility

Reaction optimization SV and BSV setup
The single vessel SV and BSV setup provide vessels for the full optimization of a reaction for research or teaching purposes.
This package includes a 45 mL quartz vessel which allows to perform reactions at temperature up to 250°C and pressure up to 40 bar.
The vessel is hosted in a safety shield which features a built-in pressure control through a preloaded spring with vent-and-reseal mechanism.
A special PTFE cover is equipped with ports for direct temperature and pressure control. An optional cover permits to flush the reactor with inert gas, or to pre-load a gaseous reactant for gas-liquid reactions.
Rapid cooling is ensured by a stream of compressed air.
The SV package also includes a PTFE reaction vessel with a PEEK shield, suitable for all the applications where improved chemical resistance is required, or higher pressures (up to 100 bar) are expected.
 

Large batch reactions NP setup
The normal pressure NP reactors allow chemists to perform synthetic reactions under reflux. Ordinary laboratory glassware can also be used in the StartSYNTH.
In this way, any chemical reaction currently performed with a hot plate, heating mantle or oil bath, can be immediately transferred to the microwave.
This will permit the chemist to investigate the effects of microwaves on reaction rates and mechanism.
 

Parallel format scale-up QK and SK setup
The Q-20 rotor uses up to 20 quartz vessels QV-50 and offers elevated throughput, very fast heating and cooling, and easy handling.
A fully automated capping system is also available from Milestone to enhance the automation of the synthetic process.

Synthesis of N-Alkyl-glycine methyl esters by microwave irradiation, (10 examples reported).

V. Santagada et al., Journal of Combinatorial Chemistry, 7, 2005, 618.

When scaling up a reaction under conditions of extremely high temperature and pressure, there is no better choice than the HPR rotor; this rotor accommodates up to 10 SK-10 reactors, each of which can be individually inserted in the StartSYNTH microwave cavity.

Decarboxylation of malonic acid derivatives in water.

C.L. Zara, T. Jin, R.J. Giguere, Synthetic Communications, 30 (12), 2000, 2099.