MicroSYNTH^plus

Scale-up Microwave Synthesis

The MicroSYNTH^plus labstation is the most advanced system available for microwave synthesis.
Its multimode cavity, innovative pressure vessels, sophisticated sensors and process control software easily integrate into the way you perform your chemistry.
Whether your approach to scale-up your synthesis is parallel or batch, Milestone’s microwave technology will allow you to perform more reactions in less time, with higher yields and better reproducibility than conventional methods.

Main Advantages

• Advanced microwave technology
• Precise reaction monitoring and control
• Highly effective stirring
• Exceptional scalability
• Reliable processing of single or multiple reactions simultaneously
• Rapid and reproducible method development
• No need to change your existing chemistry

Example of possible reaction

N-Alkylation of amines at 150°C for 10 minutes. Example of parallel reactions involving comparable chemistries.

Compound	Amine 1	Conversion (%)	Yield (%)
3a		100	93
3b		99	94
3c		99	81
3d		100	99

J. Alcázar, G. Diels, B. Schoentjes, QSAR & Combinatorial Science, 23, 2004, 906.