BatchSYNTH

Large Batch Scale-Up

Milestone has developed the BatchSYNTH for the scale-up of microwave-enhanced reactions.

In many scenarios, single reaction volumes of more than 100 ml are often required. Although these volumes and beyond can be processed using open glassware, there are many distinct advantages in performing reactions in closed vessels. These advantages derive from the possibility to operate at temperatures above the normal boiling point of the reaction mixtures and to safely accommodate the corresponding elevated vapor pressures.
The answer to these needs is the BatchSYNTH!

Main Advantages

• Large reactor volume
• Possibility of operation under inert atmosphere
• Reagents adding and reaction mixture sampling capabilities
• Full control of temperature, pressure, time, and microwave power
• Efficient cooling by cold finger
• Highest safety standards
• Continuous stirring of reaction mixtures to ensure homogeneity
• Powerful, easy-to-use software with full color touch screen control terminal

Example of possible application

Dearomatization of pyridine-2-carboxylic acid

E. Heller, W. Lautenschläger, U. Holzgrabe, Tetrahedron Letters, 46, 2005, 1247.